The A172 Marton Road/A174 Interchange is undergoing a major programme of repairs and improvements which are set to run until the autumn.
In the latest phase, the A174 beneath the structure will be closed eastbound on Monday (April 27), Tuesday and Wednesday nights and westbound on Thursday night.
The closures will be force between 8pm and 6am, with signed diversion routes in place.
A Middlesbrough Council spokesman said: “Some disruption is inevitable during projects of this nature, and as ever we are grateful to the public for their patience and understanding.”
